There is little doubt that psoriasis and PsA have a genetic connection, and therefore are more likely to occur in people with affected family members. In fact, one out of every three people with psoriasis has a family member with the condition. About 40% of people with psoriasis or psoriatic arthritis have close relatives with either PsA or psoriasis.

Variations in several genes have been associated with PsA and many of them are thought to play a role in how the immune system works. Overall, however, researchers believe these genes likely only have a small effect on the chances of someone developing PsA. It is more likely that other genetic and environmental factors play a greater role in whether someone develops PsA or not.

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