There is little doubt that psoriasis and PsA have a genetic connection, and therefore are more likely to occur in people with affected family members. In fact, one out of every three people with psoriasis has a family member with the condition. About 40% of people with psoriasis or psoriatic arthritis have close relatives with either PsA or psoriasis.
< Back to My Genes
Variations in several genes have been associated with PsA and many of them are thought to play a role in how the immune system works. Overall, however, researchers believe these genes likely only have a small effect on the chances of someone developing PsA. It is more likely that other genetic and environmental factors play a greater role in whether someone develops PsA or not.